AEK Atene  | 1-1 | Dinamo Kiev | Olimpico Spyros Louīs | 15 Feb | h. 19:00 |
| Astana | 1-3 |  Sporting Lisbona | Astana Arena | 15 Feb | h. 19:00 |
Borussia Dortmund  | 3-2 |  Atalanta | Westfalenstadion | 15 Feb | h. 19:00 |
Celtic Glasgow  | 1-0 | Zenit San Pietroburgo | Celtic Park | 15 Feb | h. 19:00 |
| FC Copenhagen | 1-4 |  Atletico Madrid | Telia Parken | 15 Feb | h. 19:00 |
FCSB  | 1-0 | Lazio | Stadionul Steaua | 15 Feb | h. 19:00 |
Ludogorec  | 0-3 |  Milan | Ludogorec Arena | 15 Feb | h. 19:00 |
Napoli  | 1-3 |  RB Lipsia | Diego Armando Maradona | 15 Feb | h. 19:00 |
Nizza  | 2-3 |  Lokomotiv Mosca | Allianz Riviera | 15 Feb | h. 19:00 |
| Olympique Lione | 3-1 |  Villarreal | Parc Olympique Lyonnais | 15 Feb | h. 19:00 |
Olympique Marsiglia  | 3-0 |  Sporting Braga | Stade Vélodrome | 15 Feb | h. 19:00 |
| Ostersunds | 0-3 | Arsenal | Ostersund Arena | 15 Feb | h. 19:00 |
Partizan Belgrado  | 1-1 |  Viktoria Plzen | Stadion FK Partizan | 15 Feb | h. 19:00 |
| Real Sociedad | 2-2 | Salisburgo | Reale Arena | 15 Feb | h. 19:00 |
Spartak Mosca  | 1-3 |  Athletic Bilbao | Spartak Stadium | 15 Feb | h. 19:00 |
| Stella Rossa | 0-0 |  CSKA Mosca | Stadion Rajko Mitic - Marakana | 15 Feb | h. 19:00 |