CSKA Mosca  | 1-0 | Stella Rossa | Arena CSKA Mosca | 21 Feb | h. 18:00 |
Lokomotiv Mosca  | 1-0 |  Nizza | Central Stadium Lokomotiv | 22 Feb | h. 17:00 |
Atletico Madrid  | 1-0 | FC Copenhagen | Riyadh Air Metropolitano | 22 Feb | h. 19:00 |
| Dinamo Kiev | 0-0 |  AEK Atene | NSK Olimpiyskyi | 22 Feb | h. 19:00 |
| Lazio | 5-1 |  FCSB | Olimpico | 22 Feb | h. 19:00 |
RB Lipsia  | 0-2 |  Napoli | Red Bull Arena | 22 Feb | h. 19:00 |
Sporting Lisbona  | 3-3 | Astana | José Alvalade | 22 Feb | h. 19:00 |
Viktoria Plzen  | 2-0 |  Partizan Belgrado | Plzen City Stadium | 22 Feb | h. 19:00 |
Villarreal  | 0-1 | Olympique Lione | Estadio de la Ceramica | 22 Feb | h. 19:00 |
| Zenit San Pietroburgo | 3-0 |  Celtic Glasgow | Gazprom Arena | 22 Feb | h. 19:00 |
| Arsenal | 1-2 | Ostersunds | Emirates Stadium | 22 Feb | h. 21:05 |
Atalanta  | 1-1 |  Borussia Dortmund | Mapei Stadium - Città del Tricolore | 22 Feb | h. 21:05 |
Athletic Bilbao  | 1-2 |  Spartak Mosca | Estadio de San Mames | 22 Feb | h. 21:05 |
Milan  | 1-0 |  Ludogorec | Giuseppe Meazza | 22 Feb | h. 21:05 |
| Salisburgo | 2-1 | Real Sociedad | Stadion Salzburg Wals-Siezenheim | 22 Feb | h. 21:05 |
Sporting Braga  | 1-0 |  Olympique Marsiglia | Estadio Municipal de Braga | 22 Feb | h. 21:05 |