| Siviglia | 2-0 | Lazio | Ramon Sanchez Pizjuan | 20 Feb | h. 18:00 |
| Arsenal | 3-0 |  BATE Borisov | Emirates Stadium | 21 Feb | h. 18:55 |
Dinamo Zagabria  | 3-0 |  Viktoria Plzen | Stadion Maksimir | 21 Feb | h. 18:55 |
| Eintracht Francoforte | 4-1 |  Shakhtar Donetsk | Deutsche Bank Park | 21 Feb | h. 18:55 |
Napoli  | 2-0 | Zurigo | Diego Armando Maradona | 21 Feb | h. 18:55 |
| Salisburgo | 4-0 |  Club Bruges | Stadion Salzburg Wals-Siezenheim | 21 Feb | h. 18:55 |
Valencia  | 1-0 |  Celtic Glasgow | Estadio de Mestalla | 21 Feb | h. 18:55 |
| Villarreal | 1-1 |  Sporting Lisbona | Estadio de la Ceramica | 21 Feb | h. 18:55 |
| Zenit San Pietroburgo | 3-1 |  Fenerbahce | Gazprom Arena | 21 Feb | h. 18:55 |
Bayer Leverkusen  | 1-1 |  Krasnodar | BayArena | 21 Feb | h. 21:00 |
Benfica  | 0-0 |  Galatasaray | Estadio da Luz | 21 Feb | h. 21:00 |
Chelsea  | 3-0 | Malmo FF | Stamford Bridge | 21 Feb | h. 21:00 |
| Dinamo Kiev | 1-0 | Olympiakos | NSK Olimpiyskyi | 21 Feb | h. 21:00 |
Genk  | 1-4 | Slavia Praga | KRC Genk Arena | 21 Feb | h. 21:00 |
Inter  | 4-0 | Rapid Vienna | Giuseppe Meazza | 21 Feb | h. 21:00 |
Real Betis  | 1-3 | Stade Rennes | Estadio Benito Villamarín | 21 Feb | h. 21:00 |