| Dinamo Zagabria | 1-0 |  Benfica | Stadion Maksimir | 7 Mar | h. 18:55 |
Eintracht Francoforte  | 0-0 |  Inter | Commerzbank-Arena | 7 Mar | h. 18:55 |
Siviglia  | 2-2 |  Slavia Praga | Ramon Sanchez Pizjuan | 7 Mar | h. 18:55 |
Stade Rennes  | 3-1 |  Arsenal | Stade de la Route de Lorient | 7 Mar | h. 18:55 |
Zenit San Pietroburgo  | 1-3 |  Villarreal | Saint Petersburg Stadium | 7 Mar | h. 18:55 |
| Chelsea | 3-0 |  Dinamo Kiev | Stamford Bridge | 7 Mar | h. 21:00 |
Napoli  | 3-0 |  RB Salisburgo | San Paolo | 7 Mar | h. 21:00 |
Valencia  | 2-1 | Krasnodar | Estadio de Mestalla | 7 Mar | h. 21:00 |
