| Inter | 2-1 | Fiorentina | Giuseppe Meazza | 25 Set | h.21:00 |
| Udinese | 1-2 | Lazio | Bluenergy Stadium - Stadio Friuli | 26 Set | h.19:00 |
| Atalanta | 0-0 | Torino | Gewiss Stadium | 26 Set | h.21:00 |
| Cagliari | 0-0 | Sampdoria | Unipol Domus | 26 Set | h.21:00 |
| Genoa | 2-0 | ChievoVerona | Luigi Ferraris | 26 Set | h.21:00 |
| Juventus | 2-0 | Bologna | Allianz Stadium | 26 Set | h.21:00 |
| Napoli | 3-0 | Parma | Diego Armando Maradona | 26 Set | h.21:00 |
| Roma | 4-0 | Frosinone | Olimpico | 26 Set | h.21:00 |
| SPAL | 0-2 | Sassuolo | Paolo Mazza | 27 Set | h.19:00 |
| Empoli | 1-1 | Milan | Carlo Castellani - Computer Gross Arena | 27 Set | h.21:00 |