| Juventus | 3-0 | Frosinone | Allianz Stadium | 15 Feb | h.20:30 |
| Cagliari | 2-1 | Parma | Unipol Domus | 16 Feb | h.18:00 |
| Atalanta | 1-3 | Milan | Gewiss Stadium | 16 Feb | h.20:30 |
| SPAL | 1-4 | Fiorentina | Paolo Mazza | 17 Feb | h.12:30 |
| Empoli | 3-0 | Sassuolo | Carlo Castellani - Computer Gross Arena | 17 Feb | h.15:00 |
| Genoa | 2-1 | Lazio | Luigi Ferraris | 17 Feb | h.15:00 |
| Udinese | 1-0 | ChievoVerona | Bluenergy Stadium - Stadio Friuli | 17 Feb | h.15:00 |
| Inter | 2-1 | Sampdoria | Giuseppe Meazza | 17 Feb | h.18:00 |
| Napoli | 0-0 | Torino | Diego Armando Maradona | 17 Feb | h.20:30 |
| Roma | 2-1 | Bologna | Olimpico | 18 Feb | h.20:30 |