Panathinaikos  | 2-2 |  Dnipro-1 | Apostolos Nikolaidis | 1 Ago | h. 19:30 |
| BATE Borisov | 3-5 | Aris Limassol | Barysau Arena | 1 Ago | h. 20:00 |
Olimpia Lubiana  | 2-1 | Ludogorec | Stožice | 1 Ago | h. 20:00 |
Slovan Bratislava  | 2-2 | Zrinjski Mostar | Stadion Pasienky | 1 Ago | h. 20:30 |
| Astana | 0-2 | Dinamo Zagabria | Astana Arena | 2 Ago | h. 16:00 |
| Qarabag | 1-1 | Rakow Czestochowa | Tofig Bahramov Republican Stadium | 2 Ago | h. 18:00 |
Genk  | 1-4 (d.c.r) | Servette | KRC Genk Arena | 2 Ago | h. 19:00 |
Hacken  | 3-4 (d.c.r) |  KI Klaksvík | 2 Ago | h. 19:00 | |
Maccabi Haifa  | 4-1 (d.t.s) |  Sheriff Tiraspol | Sammy Ofer | 2 Ago | h. 19:00 |
| Molde | 2-0 |  HJK Helsinki | Aker Stadion | 2 Ago | h. 19:00 |
FC Copenhagen  | 6-3 | Breidablik | Telia Parken | 2 Ago | h. 20:00 |
Galatasaray  | 1-0 | Zalgiris Vilnius | Atatürk Olympic Stadium | 2 Ago | h. 20:30 |