| Apoel Nicosia | 2-0 | Slavia Praga | GSP | 15 Ago | h. 20:45 |
| Hoffenheim | 1-2 |  Liverpool | Wirsol Rhein-Neckar-Arena | 15 Ago | h. 20:45 |
Qarabag  | 1-0 | Copenaghen | Tofig Bahramov Republican Stadium | 15 Ago | h. 20:45 |
Sporting Lisbona  | 0-0 | Steaua Bucarest | José Alvalade | 15 Ago | h. 20:45 |
| Young Boys | 0-1 | CSKA Mosca | Stade de Suisse | 15 Ago | h. 20:45 |
| Celtic Glasgow | 5-0 |  Astana | Celtic Park | 16 Ago | h. 20:45 |
Hapoel Beer Sheva  | 2-1 | Maribor | Turner Stadium | 16 Ago | h. 20:45 |
| Istanbul Basaksehir | 1-2 |  Siviglia | Fatih Terim Stadium | 16 Ago | h. 20:45 |
| Napoli | 2-0 |  Nizza | San Paolo | 16 Ago | h. 20:45 |
| Olympiacos | 2-1 | Rijeka | Stadio Georgios Karaiskakis | 16 Ago | h. 20:45 |
