| Udinese | 1-1 | Lecce | Bluenergy Stadium - Stadio Friuli | 4 Nov | h.20:45 |
| Empoli | 1-0 | Sassuolo | Carlo Castellani - Computer Gross Arena | 5 Nov | h.15:00 |
| Salernitana | 2-2 | Cremonese | Arechi | 5 Nov | h.15:00 |
| Atalanta | 1-2 | Napoli | Gewiss Stadium | 5 Nov | h.18:00 |
| Milan | 2-1 | Spezia | Giuseppe Meazza | 5 Nov | h.20:45 |
| Bologna | 2-1 | Torino | Renato Dall'Ara | 6 Nov | h.12:30 |
| Monza | 2-0 | Verona | U-Power Stadium | 6 Nov | h.15:00 |
| Sampdoria | 0-2 | Fiorentina | Luigi Ferraris | 6 Nov | h.15:00 |
| Roma | 0-1 | Lazio | Olimpico | 6 Nov | h.18:00 |
| Juventus | 2-0 | Inter | Allianz Stadium | 6 Nov | h.20:45 |