| Aston Villa | 1-1 | Leeds United | Villa Park | 21 Feb | h.16:00 | |
| Brentford | 0-2 | Brighton & Hove Albion | Griffin Park | 21 Feb | h.16:00 | |
| Chelsea | 1-1 | Burnley | Stamford Bridge | 21 Feb | h.16:00 | |
| West Ham United | 0-0 | Bournemouth | The Stadium | 21 Feb | h.18:30 | |
| Manchester City | 2-1 | Newcastle United | City of Manchester Stadium | 21 Feb | h.21:00 | |
| Crystal Palace | 1-0 | Wolverhampton Wanderers | Selhurst Park | 22 Feb | h.15:00 | |
| Nottingham Forest | 0-1 | Liverpool | City Ground | 22 Feb | h.15:00 | |
| Sunderland | 1-3 | Fulham | Stadium of Light | 22 Feb | h.15:00 | |
| Tottenham Hotspur | 1-4 | Arsenal | Tottenham Hotspur Stadium | 22 Feb | h.17:30 | |
| Everton | - | Manchester United | Goodison Park | 23 Feb | h.21:00 |