| AZ Alkmaar | - | Noah | AFAS Stadion | 26 Feb | h. 21:00 |
| Celje | - | Drita | Stadio Z'dežele | 26 Feb | h. 21:00 |
| Crystal Palace | - | Zrinjski Mostar | Selhurst Park | 26 Feb | h. 21:00 |
| Fiorentina | - | Jagiellonia Byalistok | Artemio Franchi | 26 Feb | h. 21:00 |
| Lech Poznan | - | KuPS Kuopio | Stadion Miejski | 26 Feb | h. 21:00 |
| Losanna | - | Sigma Olomouc | Stade Olympique de la Pontaise | 26 Feb | h. 21:00 |
| Rijeka | - | Omonia Nicosia | Stadion HNK Rijeka | 26 Feb | h. 21:00 |
| Samsunspor | - | Shkendija | 26 Feb | h. 21:00 |