| Celje | 3-2 | Drita | Stadio Z'dežele | 26 Feb | h. 18:45 |
| Fiorentina | 2-4 (d.t.s) | Jagiellonia Byalistok | Artemio Franchi | 26 Feb | h. 18:45 |
| Rijeka | 3-1 | Omonia Nicosia | Stadion HNK Rijeka | 26 Feb | h. 18:45 |
| Samsunspor | 4-0 | Shkendija | Samsun 19 Mayıs Stadium | 26 Feb | h. 18:45 |
| AZ Alkmaar | 4-0 | Noah | AFAS Stadion | 26 Feb | h. 21:00 |
| Crystal Palace | 2-0 | Zrinjski Mostar | Selhurst Park | 26 Feb | h. 21:00 |
| Lech Poznan | 1-0 | KuPS Kuopio | Stadion Miejski | 26 Feb | h. 21:00 |
| Losanna | 1-2 | Sigma Olomouc | Stade de la Tuilière | 26 Feb | h. 21:00 |