| Bayer Leverkusen | 0-1 |  Atalanta | BayArena | 17 Mar | h. 18:45 |
| Galatasaray | 1-2 |  Barcellona | Türk Telekom Arena | 17 Mar | h. 18:45 |
| Monaco | 1-1 |  Sporting Braga | Stade Louis II | 17 Mar | h. 18:45 |
| Stella Rossa | 2-1 |  Glasgow Rangers | Stadion Rajko Mitić - Marakana | 17 Mar | h. 18:45 |
| Eintracht Francoforte | 1-1 (d.t.s) |  Betis | Deutsche Bank Park | 17 Mar | h. 21:00 |
| Olympique Lione | 1-1 |  Porto | Parc Olympique Lyonnais | 17 Mar | h. 21:00 |
| Spartak Mosca | 0-3 |  RB Lipsia | Spartak Stadium | 17 Mar | h. 21:00 |
| West Ham | 2-0 (d.t.s) |  Siviglia | The Stadium | 17 Mar | h. 21:00 |