| Atalanta | 0-1 | Real Madrid | Gewiss Stadium | 16 Feb | h. 21:00 |
Atletico Madrid  | 0-1 |  Chelsea | Riyadh Air Metropolitano | 16 Feb | h. 21:00 |
Barcellona  | 1-4 |  Paris Saint Germain | Camp Nou | 16 Feb | h. 21:00 |
Borussia Monchengladbach  | 0-2 |  Manchester City | Borussia-Park | 16 Feb | h. 21:00 |
Lazio  | 1-4 | Bayern Monaco | Olimpico | 16 Feb | h. 21:00 |
| Porto | 2-1 | Juventus | Estadio do Dragao | 16 Feb | h. 21:00 |
| RB Lipsia | 0-2 | Liverpool | Puskas Arena | 16 Feb | h. 21:00 |
| Siviglia | 2-3 | Borussia Dortmund | Ramon Sanchez Pizjuan | 16 Feb | h. 21:00 |