| Monza U20 | 2-0 | Sampdoria U20 | Centro Sportivo Silvio e Luigi Berlusconi | 10 Nov | h.14:30 |
| Lazio U20 | 2-0 | Torino U20 | CS Formello, Campo Mirko Fersini | 11 Nov | h.11:00 |
| Juventus U20 | 1-4 | Atalanta U20 | Juventus Training Center, Campo Ale e Ricky | 11 Nov | h.13:00 |
| Genoa U20 | 2-0 | Frosinone U19 | Comunale Chittolina | 11 Nov | h.14:00 |
| Milan U20 | 2-0 | Lecce U20 | PUMA House of Football - CS Peppino Vismara | 12 Nov | h.10:45 |
| Cagliari U20 | 0-2 | Roma U20 | C.S. Asseminello, Campo Campioni d'Italia 1969-70 | 12 Nov | h.11:00 |
| Fiorentina U20 | 1-1 | Empoli U20 | Rocco Commisso Viola Park (Stadio Curva Fiesole) | 12 Nov | h.13:00 |
| Bologna U20 | 1-2 | Sassuolo U20 | Centro tecnico Niccolò Galli | 12 Nov | h.14:00 |
| Verona U20 | 1-1 | Inter U20 | Synergy Stadium | 12 Nov | h.16:00 |