Astra Giurgiu  | 2-2 | Genk | 16 Feb | h. 17:00 | |
| Krasnodar | 1-0 | Fenerbahce | Stadium Krasnodar | 16 Feb | h. 17:00 |
| AZ Alkmaar | 1-4 |  Olympique Lione | AFAS Stadion | 16 Feb | h. 19:00 |
Borussia Monchengladbach  | 0-1 | Fiorentina | Borussia-Park | 16 Feb | h. 19:00 |
Celta Vigo  | 0-1 | Shakhtar Donetsk | Balaidos | 16 Feb | h. 19:00 |
KAA Gent  | 1-0 |  Tottenham Hotspur | KAA Gent Stadium | 16 Feb | h. 19:00 |
Ludogorec  | 1-2 |  FC Copenhagen | Natsionalen Stadion Vasil Levski | 16 Feb | h. 19:00 |
Olympiakos  | 0-0 |  Osmanlispor | Georgios Karaiskakis | 16 Feb | h. 19:00 |
Rostov  | 4-0 | Sparta Praga | Olimp 2 | 16 Feb | h. 19:00 |
| Anderlecht | 2-0 | Zenit San Pietroburgo | Constant Vanden Stock Stadium | 16 Feb | h. 21:05 |
Athletic Bilbao  | 3-2 | APOEL | Estadio de San Mames | 16 Feb | h. 21:05 |
Hapoel Beer Sheva  | 0-0 |  Besiktas | Turner Stadium | 16 Feb | h. 21:05 |
Legia Varsavia  | 0-0 | Ajax | Stadion Vojska Polskiego | 16 Feb | h. 21:05 |
| Manchester United | 3-0 | Saint Etienne | Old Trafford | 16 Feb | h. 21:05 |
PAOK  | 0-3 |  Schalke 04 | Toumba Stadium | 16 Feb | h. 21:05 |
| Villarreal | 0-4 | Roma | Estadio de la Ceramica | 16 Feb | h. 21:05 |