| Brighton | 0-0 | Crystal Palace | The Amex Stadium | 28 Nov | h.20:45 |
| Leicester | 2-1 | Tottenham | King Power Stadium | 28 Nov | h.20:45 |
| Watford | 2-4 | Manchester United | Vicarage Road | 28 Nov | h.21:00 |
| West Bromwich | 2-2 | Newcastle | The Hawthorns | 28 Nov | h.21:00 |
| Arsenal | 5-0 | Huddersfield Town | Emirates Stadium | 29 Nov | h.20:45 |
| Bournemouth | 1-2 | Burnley | Dean Court | 29 Nov | h.20:45 |
| Chelsea | 1-0 | Swansea City | Stamford Bridge | 29 Nov | h.20:45 |
| Everton | 4-0 | West Ham | Goodison Park | 29 Nov | h.21:00 |
| Manchester City | 2-1 | Southampton | City of Manchester Stadium | 29 Nov | h.21:00 |
| Stoke City | 0-3 | Liverpool | Bet365 Stadium | 29 Nov | h.21:00 |
